Defibrotide

Breastfeeding
  • TRADE NAME: Defitelio (Jazz)
  • INDICATIONS: Hepatic veno-occlusive disease in patients with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation
  • CLASS: Oligonucleotide
  • HALF-LIFE: <2 hours

FDA APPROVAL DATE: 03/30/2016

CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:

Alteplase, Heparin

PREGNANCY CATEGORY: N/A
No data available

Contra-indicated for concomitant administration with systemic anticoagulant or fibrinolytic therapy.

Our database has 31 adverse reactions for this drug across the following areas

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SKIN
MUCOSAL
CARDIOVASCULAR
CENTRAL NERVOUS SYSTEM
GASTROINTESTINAL/HEPATIC
RESPIRATORY
ENDOCRINE/METABOLIC
RENAL
HEMATOLOGIC
LOCAL
OTHER


Page last updated 09/19/2018

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Incidence info

  • <1%
  • 1-5%
  • 5-10%
  • 10-15%
  • 15-20%
  • 20-30%
  • >30%

Seriousness info

  • Hospitalization possible
  • Life threatening
  • Fatal

Warnings in other populations info

  • Breast feeding
  • Geriatric
  • Pediatric