Irbesartan
- TRADE NAMES: Aprovel (Bristol-Myers Squibb); Avalide (Bristol-Myers Squibb); Avapro (Sanofi-Aventis)
- INDICATIONS: Hypertension, diabetic nephropathy
- CLASS: Angiotensin receptor antagonist (blocker), Antihypertensive
- HALF-LIFE: 11–15 hours
ACE inhibitors, Adrenergic neurone blockers, Alcohol, Aldesleukin, Aldosterone antagonists, Aliskiren, Alpha blockers, Alprostadil, Amifostine, Antihypertensives, Antipsychotics, Anxiolytics and hypnotics, Baclofen, Beta blockers, Calcium channel blockers, Carvedilol, Clonidine, Corticosteroids, Cyclosporine, CYP2C8 and CYP2C9 substrates, Diazoxide, Diuretics, Eplerenone, Fluconazole, General anesthetics, Heparins, Hypotensives, Levodopa, Lithium, MAO inhibitors, Methyldopa, Methylphenidate, Moxisylyte, Moxonidine, Nitrates, NSAIDs, Pentoxifylline, Phosphodiesterase 5 inhibitors, Potassium salts, Prostacyclin analogues, Rifamycin derivatives, Rituximab, Tacrolimus, Tizanidine, Tolvaptan, Trimethoprim
PREGNANCY CATEGORY: D
category C in first trimester; category D in second and third trimesters
Avalide is irbesartan and hydrochlorothiazide.
Hydrochlorothiazide is a sulfonamide which can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome
See full prescribing information for complete boxed warning.
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Page last updated 03/13/2024
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Incidence
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric